Thomas Madison (1746–1798) was a soldier and politician in Revolutionary-era Virginia.
He was born in Augusta County, Virginia, the son of John and Agatha (Strother) Madison; his brothers included the Reverend James Madison and Governor George Madison. He was a second cousin to United States President James Madison.
He was one of the 13 signers of the Fincastle Resolutions in 1775. He served as sheriff of Augusta County and as a commissary during the 1776 expedition against the Cherokees. His wife was Susanna Henry, sister of Virginia governor Patrick Henry.